MRI Mouse Brain Data of Ischemic Lesion after Transient Middle Cerebral Artery Occlusion
نویسندگان
چکیده
1 Department of Neurology, Leiden University Medical Center, Leiden, Netherlands, 2 Division of Image Processing (LKEB), Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 3 Percuros B.V., Department of Developmental Bio-Engineering, University of Twente, Enschede, Netherlands, 4 Department of Radiation Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands, 5 Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands, 6 In-Vivo-NMR Laboratory, Max Planck Institute for Metabolism Research, Cologne, Germany, 7 Intelligent Systems Group, Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of
منابع مشابه
Research Paper: Optimization of Transient Focal Cerebral Ischemia Model by Middle Cerebral Artery Occlusion
Introduction: Cerebral ischemia is one of the most common causes of death in human populations in the industrial communities. The need for animal models is inevitable to study the pathophysiology and treatment of cerebral ischemia in human. The current study aimed at evaluating the strengths and weaknesses of different techniques used to create ischemia in previous studies and optimizing the tr...
متن کاملStratification of heterogeneous diffusion MRI ischemic lesion with kurtosis imaging: evaluation of mean diffusion and kurtosis MRI mismatch in an animal model of transient focal ischemia.
BACKGROUND AND PURPOSE Ischemic tissue damage is heterogeneous, resulting in complex patterns in the widely used diffusion-weighted MRI. Our study examined the spatiotemporal characteristics of diffusion kurtosis imaging in an animal model of transient middle cerebral artery occlusion. METHODS Adult male Wistar rats (N=18) were subjected to 90 minutes middle cerebral artery occlusion. Multipa...
متن کاملAn optimized mouse model for transient ischemic attack.
Transient ischemic attacks (TIAs) are brief neurological deficits ofcerebrovascular origin that are followed by complete clinical recovery. Although a plethora of animal models exist for ischemic stroke, a verified TIA model is lacking. We aimed to optimize such a model in mice, investigating the impact of varying durations (from 2.5 to 20 minutes) of intraluminal middle cerebral artery occlusi...
متن کاملبررسی اثر انسداد گذرای شریان مرکزی در کاهش آسیبهای مغزی در مدل سکتهی مغزی رت
Background and Objective: Recent studies suggest that sub-lethal ischemia protect the brain from subsequent ischemic injuries. This study was an effort to identify and shed light on the nature of changes in the blood brain barrier permeability and brain edema. Materials and Methods: Rats were divided into four main experimental groups, each of 21 animals. The first group acted as a model of isc...
متن کاملInhibition of nitric oxide synthase activity improves focal cerebral damage induced by cerebral ischemia/reperfusion in normotensive rats
Introduction: Nitric oxide seems to play a dual role in ischemia/reperfusion injury. Few studies have investigated whether it exacerbates or improves brain edema. In the present study, we inhibited the activity of nitric oxide synthase by L-NAME and evaluated the cerebral infarct volume, tissue swelling and brain edema, alongside the measurement of blood flow of the ischemic region. Methods...
متن کاملAutomated Ischemic Lesion Segmentation in MRI Mouse Brain Data after Transient Middle Cerebral Artery Occlusion
Magnetic resonance imaging (MRI) has become increasingly important in ischemic stroke experiments in mice, especially because it enables longitudinal studies. Still, quantitative analysis of MRI data remains challenging mainly because segmentation of mouse brain lesions in MRI data heavily relies on time-consuming manual tracing and thresholding techniques. Therefore, in the present study, a fu...
متن کامل